How does SARS-CoV-2 evade the immune defences?

As most of pathogens, SARS-CoV-2 can be recognized by pattern recognition receptors on innate. Normally, this recognition helps the innate immunity to eliminate the infection or to activate the adaptive immune responses, however, SARS-CoV-2 can use its proteins such as M, N, NSP1 and PLpro to interfere with these pathways.

Frontiers Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past

Innate immune sensing of coronavirus and viral evasion strategies

How Effective Are COVID-19 Vaccines in Immunocompromised People?

Innate immune sensing of coronavirus and viral evasion strategies

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 - ScienceDirect

Why Viruses Like SARS-CoV-2 Can Reinfect Us, Evade Immune Response

How COVID-19 variants evade immune response

Potential immune evasion mechanisms shared by SARS-CoV, MERS-CoV and

Natural Killer Cells: Taking on SARS-CoV-2

A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species

Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection