Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

Marko Košiček - Science communication coordinator - Ruđer Bošković

Lysosomal dysfunction as a common mechanism of neurodegenerative

Martina MALNAR, PostDoc, PhD

Critical role for glycosphingolipids in Niemann-Pick disease type

Frontiers Dissecting the Molecular Mechanisms of

PDF] Molecular mechanisms of neurodegeneration in Alzheimer's

PDF) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in

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Molecular mechanism(s) of cholesterol-effect on APP and BACE1

Niemann–Pick type C disease: cellular pathology and

mRNA Treatment Rescues Niemann–Pick Disease Type C1 in Patient