Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.

Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?

Temozolomide (NSC 362856), DNA Alkylator

Temozolomide-d3, Stable Isotope

Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?

Imidazolecarboxamide - an overview

Phase I and Pharmacokinetic Study of Temozolomide on a Daily-for-5-Days Schedule in Patients With Advanced Solid Malignancies

Table 1 from Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Temozolomide, CAS:85622-93-1, DNA-methylating antitumor agent; also induces autophagy, High Purity

Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide in: Journal of Neurosurgery Volume 99 Issue 6 (2003) Journals

Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture

Temozolomide American Journal of Cancer

Selleck Chemical LLC Temozolomide 100mg 85622-93-1 CCRG81045, NSC 362856,TMZ