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PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions

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Last updated 17 novembro 2024

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP: Cell

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer's disease, Cell Communication and Signaling

Local PI(4,5)P2 signaling inhibits fusion pore expansion during exocytosis - ScienceDirect

Lateral Organization of PI(4,5)P2

Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains

PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans

PMP2/FABP8 induces PI(4,5)P2-dependent transbilayer reorganization of sphingomyelin in the plasma membrane - ScienceDirect

PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions

A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2) - ScienceDirect

Molecules, Free Full-Text

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

A PI(4,5)P2‐derived “gasoline engine model” for the sustained B cell receptor activation - Xu - 2019 - Immunological Reviews - Wiley Online Library

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