Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children, International Journal of Emergency Medicine

Cerebrospinal fluid (CSF) lactate is a potential biomarker for bacterial meningitis in children. To this end, we performed a single-center retrospective cohort study of children from Sao Paulo, Brazil, with CSF pleocytosis to evaluate the ability of CSF lactate to distinguish between children with bacterial and aseptic meningitis. We determined the optimum cutoff point for CSF lactate using receiver-operator curve (ROC) analysis. We identified 451 children of whom 40 (9%) had bacterial meningitis. Children with bacterial meningitis had a higher median CSF lactate level [9.6 mmol/l, interquartile range (IQR) 3.2-38.5 mmol/l bacterial meningitis vs. 2.0 mmol/l, IQR 1.2-2.8 mmol/l aseptic meningitis]. A CSF lactate cutoff point of 3.0 mmol/l had a sensitivity of 95% [95% confidence interval (CI) 83-99%), specificity of 94% (95% CI 90-96%) and negative predictive value of 99.3% (95% CI 97.7-99.9%) for bacterial meningitis. In combination with a validated meningitis clinical prediction rule, the CSF lactate level can be used to distinguish between bacterial and aseptic meningitis in children with CSF pleocytosis.

The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis.

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

Comparison between cerebrospinal fluid biomarkers for differential diagnosis of acute meningitis

PDF] Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis.

Serum and cerebrospinal fluid heparin-binding protein levels in differentiating acute bacterial from nonbacterial meningitis El-Lehleh AM, Bader EA, Markous AS, Elhamouly MS - Menoufia Med J

Full article: Study of cerebrospinal fluid levels of lactate, lactate dehydrogenase and adenosine deaminase in the diagnosis and outcome of acute meningitis

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

Cerebrospinal fluid findings and hypernatremia in COVID-19 patients with altered mental status, International Journal of Emergency Medicine

SOP: emergency workup in patients with suspected acute bacterial meningitis, Neurological Research and Practice

Comparison between cerebrospinal fluid biomarkers for differential diagnosis of acute meningitis

African Journal of Microbiology Research - etiological and predictive factors of acute meningitis in mansoura fever hospital, egypt

S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version), Neurological Research and Practice

PDF) Cerebrospinal fluid analysis acute bacterial versus viral meningitis