Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery

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Last updated 18 outubro 2024

$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, β-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.

$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

Comparing Labetalol and Nitroglycerine on Inducing Controlled Hypotension and Intraoperative Blood Loss in Rhinoplasty: A Single-Blinded Clinical Trial, Anesthesiology and Pain Medicine

$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

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$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

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$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial - Raheem - 2012 - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library

$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

European Stroke Organisation (ESO) guidelines on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage - Else Charlotte Sandset, Craig S Anderson, Philip M Bath, Hanne Christensen, Urs Fischer, Dariusz Gąsecki

$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

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$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

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$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

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$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$

Full article: Remifentanil versus labetalol for deliberate hypotensive anesthesia in children undergoing cochlear implantation: A randomized clinical trial

$Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery$